(R)-Cetirizine EP Impurity G DiHCl CAS 728948-88-7
| CAS No. | 728948-88-7 |
| Molecular Formula | C19H23ClN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-Cetirizine EP Impurity G DiHCl.
CATO supplies (R)-Cetirizine EP Impurity G DiHCl (CAS 728948-88-7), a pharmacopoeial impurity reference standard (molecular formula C19H23ClN2OHCl, MW 367.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, (R)-Cetirizine EP Impurity G DiHCl (C19H23ClN2OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 367.31 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), (R)-Cetirizine EP Impurity G DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H23ClN2O 2*HCl |
| Molecular Weight | 367.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related R Standards
- Cetirizine EP Impurity B (CAS 1000690-91-4)
- Cetirizine Impurity 10 (CAS 1016-78-0)
- rac Cetirizine N-Oxide (Mixture of Diastereomers) (CAS 1076199-80-8)
- Cetirizine USP Related Compound B (CAS 108983-83-1)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- (R)-Cetirizine-d4 Dihydrochloride (CAS 1133210-23-7)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
Recommended Standards
- Epalrestat impurity 37 (CAS CATO-C4X-223637)
- Dotinurad impurity 107 (CAS CATO-C4X-2494107)
- Ribavirin Impurity 11 (CAS 39925-10-5)
- 5-amino-1-benzyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 905244-78-2)
- (3-Fluorophenyl)(1-methyl-1H-pyrrol-2-yl)methanol (CAS 1443305-30-3)
- tert-Butyl 2-(hydroxymethyl)-2-methylazepane-1-carboxylate (CAS 1785541-37-8)
- 2,3-Dihydro-1H-cyclopenta[c]quinoline-4-thiol (CAS 15882-29-8)
- 1-(3-(Difluoromethoxy)phenyl)ethan-1-amine hcl (CAS 926263-64-1)
- 3-(Cyclohexyloxy)propanimidamide hydrochloride (CAS 1210660-47-1)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
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