Cetirizine Impurity N19 CAS 113740-61-7
| CAS No. | 113740-61-7 |
| Molecular Formula | C19H21ClN2O2 |
| Molecular Weight | 344.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Cetirizine Impurity N19 (C19H21ClN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 344.84 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Cetirizine Impurity N19 (CAS 113740-61-7, C19H21ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cetirizine Impurity N19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H21ClN2O2 |
| Molecular Weight | 344.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine Dihydrochloride EP Impurity B (CAS 942193-17-1)
- Cetirizine Impurity 37 (CAS CATO-C4X-158237)
- Cetirizine EP Impurity F (CAS 83881-53-2)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- Cetirizine Impurity 26 (CAS CATO-C4X-158226)
- Cetirizine Impurity 36 (CAS CATO-C4X-158236)
- Cetirizine Impurity 35 (CAS CATO-C4X-158235)
- Cetirizine USP Related Compound C (CAS 83881-37-2)
Recommended Standards
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- Loratadine Impurity 29 (CAS 125743-81-9)
- Fulvestrant impurity 55 (CAS CATO-C4X-191755)
- Finerenone Impurity 182-d5 (CAS CATO-C4X-2880182)
- Meropenem Impurity 41 (CAS CATO-C4X-130941)
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