Lifitegrast Impurity 28 CAS 73075-47-5
| CAS No. | 73075-47-5 |
| Molecular Formula | C9H9Cl2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Lifitegrast Impurity 28 (CAS 73075-47-5), a pharmacopoeial impurity reference standard (molecular formula C9H9Cl2NHCl, MW 238.54 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lifitegrast Impurity 28 (C9H9Cl2NHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9Cl2N HCl |
| Molecular Weight | 238.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lifitegrast Standards
- Lifitegrast (CAS 1025967-78-5)
- Lifitegrast Impurity 37 (CAS 1194550-56-5)
- Lifitegrast Impurity 49 (CAS 1194550-59-8)
- Lifitegrast Impurity 30 (CAS 1194550-61-2)
- Lifitegrast Impurity 23 (CAS 1194550-65-6)
- Lifitegrast Impurity 11 (CAS 1194550-67-8)
- Lifitegrast Impurity 39 (CAS 1194864-16-8)
- Lifitegrast Impurity N99 (CAS 1195655-47-0)
Recommended Standards
- Sildenafil Impurity 256 (CAS 1027192-9-2)
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- Edaravone Impurity 16 (CAS CATO-C4X-106216)
- 4-Hydroxy-2-iodobenzonitrile (CAS 1243386-89-1)
- Docos-21-en-1-yltriethoxysilane (CAS 330457-44-8)
- 3-(3-Fluorophenyl)piperidine hydrochloride (CAS 100240-20-8)
- 2-(Phenylsulfonyl)-1-(5-(phenylsulfonyl)furan-2-yl)ethanone (CAS 853334-11-9)
- Tert-butyl (Z)-(4-bromo-3-fluorobut-2-en-1-yl)carbamate (CAS 1098972-51-0)
- tert-Butyl (S)-4-amino-3,3-dimethylpiperidine-1-carboxylate (CAS 1357600-60-2)
- Des-Val23-Tirzepatide (CAS CATO-CPTD788950)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com