Lifitegrast Impurity 37 CAS 1194550-56-5

Description

Compared with other compounds in its class, the molecular weight of 488.40 g/mol gives Lifitegrast Impurity 37 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Lifitegrast Impurity 37 (CAS 1194550-56-5), a pharmacopoeial impurity reference standard (molecular formula C29H23Cl2NO2, MW 488.40 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Lifitegrast Impurity 37 (C29H23Cl2NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Lifitegrast Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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