Nifedipine Impurity 25 CAS 73372-63-1
| CAS No. | 73372-63-1 |
| Molecular Formula | C16H14N2O6 |
| Molecular Weight | 330.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nifedipine Impurity 25 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Nifedipine Impurity 25 (CAS 73372-63-1) is a certified pharmaceutical impurity reference standard with the molecular formula C16H14N2O6 and a molecular weight of 330.29 g/mol.
Nifedipine Impurity 25 (C16H14N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14N2O6 |
| Molecular Weight | 330.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Nitrogen Atoms | 2 |
Related Nifedipine Standards
- Nifedipine Impurity 10 (CAS 114709-68-1)
- Nifedipine EP Impurity B (CAS 50428-14-3)
- Nifedipine Impurity 8 (CAS 74936-71-3)
- Nifedipine Impurity 29 (CAS CATO-C4X-141029)
- Nifedipine EP Impurity A (CAS 67035-22-7)
- Nifedipine impurity 38 (CAS CATO-C4X-141038)
- Nifedipine Metabolite (CAS 34783-31-8)
- Nifedipine Impurity 9 (CAS 21829-09-4)
Recommended Standards
- Benidipine Impurity 6 (CAS 64603-72-1)
- Aflatoxin M2 (CAS 6885-57-0)
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- Aflatoxin G2 (CAS 7241-98-7)
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- 9-Benzyl-1,4,9-triazaspiro[5.5]Undecan-5-one (CAS 1274752-07-6)
- Diammonium 2,2'-dithiodiacetate (CAS 68223-93-8)
- 2-(4-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one (CAS 860788-39-2)
- Insulin Degludec Impurity 7 (CAS CATO-C4X-21577)
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