3-Chloro-2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-5-(trifluoromethyl)pyridine CAS 735319-95-6
| CAS No. | 735319-95-6 |
| Molecular Formula | C16H13ClF3NO2 |
| Molecular Weight | 343.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-Chloro-2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-5-(trifluoromethyl)pyridine (CAS 735319-95-6), molecular formula C16H13ClF3NO2 and molecular weight 343.73 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloro-2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-5-(trifluoromethyl)pyridine (C16H13ClF3NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-Chloro-2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-5-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H13ClF3NO2 |
| Molecular Weight | 343.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-(thiazol-5-yl)phenyl trifluoromethanesulfonate (CAS 1823433-21-1)
- 1-(2-Chloro-5-(trifluoromethyl)phenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 351468-83-2)
- 1-Benzyl-3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}urea (CAS 326816-47-1)
- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide (CAS 439112-27-3)
- 4-Chloro-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]benzene-1-sulfonamide (CAS 339103-74-1)
- Benzyl 2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)propanoate (CAS 339010-47-8)
- N-(3-chloro-4-methoxybenzyl)-3-(trifluoromethyl)benzamide (CAS 478259-44-8)
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Recommended Standards
- N-(4-chlorophenyl)-2,2,2-trifluoro-N-(4-methoxybenzyl)acetamide (CAS 860649-56-5)
- Efavirenz RC 2 (CAS 173676-54-5)
- N1-[4-(tert-butyl)phenyl]-3-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]acrylamide (CAS 648859-64-7)
- N-(4-Chlorophenyl)-3-nitro-4-(1H-1,2,4-triazol-1-yl)benzamide (CAS 338407-86-6)
- 4-(4-Chlorophenyl)azetidin-2-one (CAS 21161-20-6)
- 2-iodo-5-(methylsulfanyl)benzonitrile (CAS 127049-97-2)
- 2,6-D (CAS 575-90-6)
- H-Cys(Bzl)-Gly-OH (CAS 7669-84-3)
- 4-(3,5-Dibromobenzyl)benzaldehyde (CAS 2586125-92-8)
- (5-Methyl-2-phenylfuran-3-yl)methanamine (CAS 771572-29-3)
- 3-((7,8-Dimethylquinolin-4-yl)oxy)aniline (CAS 1315346-00-9)
- 1-(3-ethyl-5-methyl-1,2-oxazol-4-yl)ethan-1-one (CAS 79379-86-5)
- 1-(1,2,3-Thiadiazol-4-yl)cyclopropan-1-ol (CAS 1484217-24-4)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
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