5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine CAS 743453-27-2
| CAS No. | 743453-27-2 |
| Molecular Formula | C11H6F3N3S2 |
| Molecular Weight | 301.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine (CAS 743453-27-2), molecular formula C11H6F3N3S2 and molecular weight 301.31 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine (C11H6F3N3S2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6F3N3S2 |
| Molecular Weight | 301.31 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Thiophen Standards
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- 2-[2-phenyl-4-(thiophen-2-yl)-1,3-thiazol-5-yl]acetic acid (CAS 23821-62-7)
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Recommended Standards
- 3-amino-6-(difluoromethyl)-4-phenylthieno[2,3-b]pyridine-2-carbonitrile (CAS 942358-04-5)
- rac Enterolactone -13C3 (CAS 918502-72-4)
- 3-{[(4-Fluorophenyl)sulfonyl]amino}-thiophene-2-carboxylic acid (CAS 926227-92-1)
- Flurbiprofen Impurity 141 (CAS 486455-73-6)
- (2E)-1-(3,4-Dichlorophenyl)-3-(4-ethylphenyl)prop-2-en-1-one (CAS 1354942-02-1)
- Methyl cis-2-(aminomethyl)cyclopropanecarboxylate (CAS 767597-03-5)
- Trifluoro-methanesulfonic acid (chloromethyl)dimethylsilyl ester (CAS 252980-64-6)
- 5-Amino-4-formylpicolinic acid (CAS 1289076-85-2)
- 5-(3,4-dihydro-2H-1-benzopyran-4-yl)-1,3,4-thiadiazol-2-amine (CAS 1342905-79-6)
- 898787-91-2 3-(4-Chlorophenyl)-1-(3-fluorophenyl)propan-1-one DTXSID30644476 (CAS 898787-91-2)
- 6-[(4-Methylphenyl)sulfanyl]-9H-purin-2-amine (CAS 225111-60-4)
- Benzyl (S)-2,3-dihydroxy-3-methylbutanoate (CAS 176505-53-6)
- Met-Enkephalin acetate salt (CAS 58569-55-4(Free Base))
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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