Flurbiprofen Impurity 141 CAS 486455-73-6
| CAS No. | 486455-73-6 |
| Molecular Formula | C17H16FNO3 |
| Molecular Weight | 301.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Flurbiprofen Impurity 141 (CAS 486455-73-6, C17H16FNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Flurbiprofen Impurity 141 (C17H16FNO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 301.31 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H16FNO3 |
| Molecular Weight | 301.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 140 (CAS 1531637-33-8)
- Flurbiprofen Impurity 129 (CAS 61467-16-1)
- Flurbiprofen Impurity 13 (CAS CATO-C4X-144413)
- Flurbiprofen Impurity 148 (CAS CATO-C4X-1444148)
- Flurbiprofen Impurity 149 (CAS CATO-C4X-1444149)
- Flurbiprofen Impurity 153 (CAS CATO-C4X-1444153)
- Flurbiprofen Impurity 170 (CAS 945721-92-6)
- Flurbiprofen Impurity 93 (CAS CATO-C4X-144493)
Recommended Standards
- rac Enterolactone -13C3 (CAS 918502-72-4)
- 2-(3,4-Dihydro-2h-1,5-benzodioxepine-7-sulfonamido)propanoic acid (CAS 1009595-24-7)
- 5-(Thiophen-2-yl)-7-(trifluoromethyl)-[1,3]thiazolo[4,5-b]pyridin-2-amine (CAS 743453-27-2)
- N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-(ethylsulfonyl)glycine (CAS 1018603-62-7)
- Entecavir Impurity 25 (CAS 110567-22-1)
- Topiroxostat Impurity 53 (CAS CATO-C4X-105553)
- Meglumine Impurity 12 (CAS CATO-C4X-214212)
- Tert-butyl (R)-2-(3-((3,3,3-trifluoropropyl)sulfonyl)propyl)pyrrolidine-1-carboxylate (CAS 1670273-30-9)
- 4-Oxo-4H-quinolizin-9-yl trifluoromethanesulfonate (CAS 951624-00-3)
- Ethyl 6-fluoro-1H-benzo[d]imidazole-4-carboxylate (CAS 1805680-72-1)
- 4-Isocyanatocyclohex-1-ene (CAS 4103-88-2)
- (7R)-octahydropyrrolo[1,2-a]pyrazin-7-ol (CAS 1426578-19-9)
- 6,8-Dibromoimidazo[1,2-α]pyrazine (CAS 63744-22-9)
- Semaglutide impurity 55 (CAS CATO-C4X-222655)
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