Edaravone Impurity 5 CAS 7477-67-0
| CAS No. | 7477-67-0 |
| Molecular Formula | C20H18N4O2 |
| Molecular Weight | 346.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Edaravone Impurity 5 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Edaravone Impurity 5 (CAS 7477-67-0), a pharmacopoeial impurity reference standard (molecular formula C20H18N4O2, MW 346.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Edaravone Impurity 5 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 346.38 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18N4O2 |
| Molecular Weight | 346.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 4 |
Related Edaravone Standards
- Edaravone Impurity 21 (CAS 177415-76-8)
- Edaravone Glucuronide (CAS 67566-02-3)
- Edaravone impurity 38 (CAS CATO-C4X-106238)
- Edaravone impurity 54 (CAS CATO-C4X-106254)
- Edaravone Impurity N5 (CAS 16394-90-4)
- Edaravone Impurity 14 (CAS CATO-C4X-106214)
- Edaravone impurity 39 (CAS CATO-C4X-106239)
- Edaravone Impurity 59 (CAS CATO-C4X-106259)
Recommended Standards
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- 2-hydroxyethyl N,N-dimethylcarbamate (CAS 3694-86-8)
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