Aprepitant Impurity 35 CAS 74974-54-2
| CAS No. | 74974-54-2 |
| Molecular Formula | C5H11ClO3 |
| Molecular Weight | 154.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Aprepitant Impurity 35 (CAS 74974-54-2, C5H11ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aprepitant Impurity 35 (C5H11ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Aprepitant Impurity 35 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H11ClO3 |
| Molecular Weight | 154.59 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
Related Aprepitant Standards
- Aprepitant Impurity 25 (CAS 78-69-3)
- Aprepitant Impurity 42 (CAS 13657-16-4)
- Aprepitant Impurity 28 (CAS 155742-64-6)
- Aprepitant Impurity 59 (CAS 1341734-61-9)
- Aprepitant impurity 33 (CAS 599162-15-9)
- Aprepitant Impurity 80 (CAS CATO-C4X-114180)
- Aprepitant impurity 51 (CAS CATO-C4X-114151)
- Aprepitant impurity 52 (CAS CATO-C4X-114152)
Recommended Standards
- (S)-3-Chlorostyrene oxide (CAS 115648-90-3)
- Acetaminophen Impurity 32 (CAS 874-60-2)
- Phenylacetyl Chloride (CAS 103-80-0)
- Roxithromycin Impurity 15 (CAS 89268-03-1)
- Spironolactone Impurity 16 (CAS CATO-C4X-134516)
- Sorafenib Impurity 14 (CAS 845306-04-9)
- Captopril EP Impurity D (CAS 56970-78-6)
- 1-(4-Bromo-6-fluoropyridin-2-yl)ethan-1-one (CAS 1393569-58-8)
- N-(4-Amino-1,2,5-oxadiazol-3-yl)-2-chloroacetamide (CAS 101140-12-9)
- 3-Hydroxy-1-(3-methylphenyl)-6-nitroquinoxalin-2(1H)-one (CAS 540514-92-9)
- n-(3,4-Difluorobenzyl)-2-methylpropan-2-amine (CAS 926236-32-0)
- 5-Methyl-2-(1-naphthylmethoxy)aniline (CAS 946682-84-4)
- SYH2092A-013213 (CAS CATO-CPTD788843)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com