Olmesartan Impurity 80 CAS 752179-89-8
| CAS No. | 752179-89-8 |
| Molecular Formula | C43H40N6O3 |
| Molecular Weight | 688.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Olmesartan Impurity 80 (C43H40N6O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Olmesartan Impurity 80 (CAS 752179-89-8, C43H40N6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Olmesartan Impurity 80 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C43H40N6O3 |
| Molecular Weight | 688.82 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 27.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 6 |
Related Olmesartan Standards
- Olmesartan impurity 11 (CAS 761404-85-7)
- Olmesartan Impurity 42 (CAS 1227626-50-7)
- Olmesartan Impurity 83 (CAS CATO-C4X-109783)
- Olmesartan Impurity 109 (CAS 1867269-66-6)
- Olmesartan impurity 102 (CAS CATO-C4X-1097102)
- Olmesartan Impurity 66 (CAS 157356-74-6)
- Olmesartan Impurity 65 (CAS 2101308-74-9)
- Olmesartan impurity 101 (CAS 2101308-73-8)
Recommended Standards
- Fmoc-Arg(c-Pr,Pbf)-OH (CAS 1060769-41-6)
- (2S,3S,4aR,8aR)-2,3-Bis[2-(diphenylphosphino)phenyl]-1,4-dimethyldecahydroquinoxaline (CAS 1562581-18-3)
- Boc-NH-PEG12-NH2 (CAS 1642551-09-4)
- Adapalene Impurity 15 (CAS CATO-C4X-180915)
- Tucatinib Impurity 2 (CAS CATO-C4X-26052)
- Varenicline Impurity 47 (CAS CATO-C4X-196247)
- Oxcarbazepine Impurity 37 (CAS CATO-C4X-116437)
- 4-(1H-Benzo[d]imidazol-2-yl)-1H-pyrazol-5-amine (CAS 111852-27-8)
- 5-Bromo-2-((3-fluorobenzyl)oxy)pyridine (CAS 2090855-71-1)
- Pentachlorobenzoylchloride (CAS 1825-23-6)
- 3-Bromo-8-methylquinolin-6-amine (CAS 858467-31-9)
- 5-bromo-3-[2-(trimethylsilyl)ethynyl]pyridin-2-ol (CAS 942589-70-0)
- tert-Butyl ((1-formylcyclopropyl)methyl)carbamate (CAS 153248-47-6)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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