Olmesartan Impurity 66 CAS 157356-74-6
| CAS No. | 157356-74-6 |
| Molecular Formula | C45H42N6O2 |
| Molecular Weight | 698.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Olmesartan Impurity 66 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Olmesartan Impurity 66 (CAS 157356-74-6) is a certified pharmaceutical impurity reference standard with the molecular formula C45H42N6O2 and a molecular weight of 698.85 g/mol.
The molecular framework of Olmesartan Impurity 66 (C45H42N6O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Olmesartan Impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C45H42N6O2 |
| Molecular Weight | 698.85 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 28.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 6 |
Related Olmesartan Standards
- Olmesartan impurity 102 (CAS CATO-C4X-1097102)
- Olmesartan Impurity 65 (CAS 2101308-74-9)
- Olmesartan impurity 101 (CAS 2101308-73-8)
- Olmesartan Impurity 49 (CAS 1418133-29-5)
- Olmesartan impurity 11 (CAS 761404-85-7)
- Olmesartan Impurity 80 (CAS 752179-89-8)
- Olmesartan Impurity 42 (CAS 1227626-50-7)
- Olmesartan Impurity 83 (CAS CATO-C4X-109783)
Recommended Standards
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- Mesna impurity 8 (CAS 74304-26-0)
- Ubrogepant Impurity 3 (CAS CATO-C4X-34023)
- Ribavirin EP Impurity F (CAS 58151-87-4)
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- N-Benzyl-1h-benzo[d][1,2,3]triazole-1-carbothioamide (CAS 690634-11-8)
- 4-[4-(Diphenylmethyl)piperazin-1-yl]-5-methoxy-2-phenylpyrimidine (CAS 477863-88-0)
- 2-(Pyrrolidin-3-yl)-1,2,3,4-tetrahydroisoquinoline (CAS 1220174-41-3)
- 4-Cyclopropylpyrazole (CAS 90253-21-7)
- Baclofen impurity 18 (CAS CATO-C4X-101218)
- 551936-17-5 3JX85UOO24 AIM-102 UNII-3JX85UOO24 (4R)-4-(((2R)-2-Amino-3-cyclohexyl-propanoyl)amino)-5-(carboxymethylamino)-5-oxo-pentanoic acid D-Cyclohexylalanine-D-glutamic-glycine tripeptide Glycine, 3-cyclohexyl-D-alanyl-D-alpha-glutamyl- (CAS 551936-17-5)
Why CATO?
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