5-Bromo-6-chloronicotinamide CAS 75291-83-7
| CAS No. | 75291-83-7 |
| Molecular Formula | C6H4BrClN2O |
| Molecular Weight | 235.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 5-Bromo-6-chloronicotinamide (CAS 75291-83-7), a certified reference material (molecular formula C6H4BrClN2O, MW 235.47 g/mol) for analytical method development and quality control.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system, 5-Bromo-6-chloronicotinamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 235.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BrClN2O |
| Molecular Weight | 235.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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- 1142192-25-3 6-Bromo-2-chloronicotinaldehyde oxime 9198AC C6H4BrClN2O (CAS 1142192-25-3)
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Recommended Standards
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- 5-Bromo-N-hydroxypicolinimidoyl chloride (CAS 702680-55-5)
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- 5-Ethyl-3-(2-methylhydrazono)indolin-2-one (CAS 677755-25-8)
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- 4-(Trifluoromethyl)-5,6,7,8-tetrahydroquinazoline-2-thiol (CAS 318258-18-3)
- (5-Bromopyridin-3-yl)(4-(thiophen-2-yl)piperidin-1-yl)methanone (CAS 1797290-54-0)
- Methyl 2-(2-chloropyrimidin-4-yl)benzoate (CAS 954234-02-7)
- 2-(Hydroxymethyl)-2-nitro-1,3-propanediol (CAS 126-11-4)
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