Leflunomide Impurity 13 CAS 75706-11-5
| CAS No. | 75706-11-5 |
| Molecular Formula | C14H14F3NO3 |
| Molecular Weight | 301.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Leflunomide Impurity 13 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Leflunomide Impurity 13 (CAS 75706-11-5) is a certified pharmaceutical impurity reference standard with the molecular formula C14H14F3NO3 and a molecular weight of 301.26 g/mol.
Structurally, Leflunomide Impurity 13 (C14H14F3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 301.26 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H14F3NO3 |
| Molecular Weight | 301.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Leflunomide Standards
- Leflunomide Impurity 20 (CAS 2734292-21-6)
- Leflunomide-d4 (CAS 1189987-23-2)
- Leflunomide EP Impurity B-d4 (Teriflunomide-d4) (CAS 1185240-22-5)
- Leflunomide (CAS 75706-12-6)
- Leflunomide EP Impurity C (CAS 61643-23-0)
- Leflunomide EP Impurity E (CAS 208401-20-1)
- Leflunomide EP Impurity F (CAS 1403564-06-6)
- Leflunomide EP Impurity B (Teriflunomide) (CAS 163451-81-8)
Recommended Standards
- Sitagliptin Impurity 82 (CAS 2248445-00-1)
- Phosmet-oxon (CAS 3735-33-9)
- Ethyl 3-dimethylamino-2-(2,3,4-trifluorobenzoyl)acrylate (CAS 783366-42-7)
- 2-(4-bromophenyl)-6-methylimidazo[1,2-<I>a</I>]pyridine (CAS 1023-01-4)
- Fingolimod 4-Hydroxy Impurity (CAS 268557-51-3)
- Osimertinib Impurity 114 (CAS CATO-C4X-2045114)
- Vortioxetine Impurity 64 (CAS 38360-81-5)
- 1,4-Diethoxytetrafluorobenzene (CAS 16251-00-6)
- (2R,3R,5S)-2-(6-Acetamido-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3-yl acetate (CAS 189887-77-2)
- 3-Bromo-L-phenylalanine (CAS 82311-69-1)
- 3-(Dimethylamino)picolinic acid (CAS 1512501-42-6)
- 1-Nitropropane (CAS 108-03-2)
- Polyquaternium 7 (CAS 26590-05-6)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com