Leflunomide EP Impurity B-d4 (Teriflunomide-d4) CAS 1185240-22-5
| CAS No. | 1185240-22-5 |
| Molecular Formula | - |
| Molecular Weight | 274.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to deuterium isotope labeling, a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Leflunomide EP Impurity B-d4 (Teriflunomide-d4) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Leflunomide EP Impurity B-d4 (Teriflunomide-d4) (CAS 1185240-22-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H5D4F3N2O2 and a molecular weight of 274.23 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Leflunomide EP Impurity B-d4 (Teriflunomide-d4) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H5D4F3N2O2 |
| Molecular Weight | 274.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Leflunomide Standards
- Leflunomide-d4 (CAS 1189987-23-2)
- Leflunomide (CAS 75706-12-6)
- Leflunomide EP Impurity C (CAS 61643-23-0)
- Leflunomide EP Impurity E (CAS 208401-20-1)
- Leflunomide EP Impurity F (CAS 1403564-06-6)
- Leflunomide EP Impurity B (Teriflunomide) (CAS 163451-81-8)
- Leflunomide Impurity 20 (CAS 2734292-21-6)
- Leflunomide Impurity 13 (CAS 75706-11-5)
Recommended Standards
- Dantrolene Impurity 3 (CAS 58136-76-8)
- Pomalidomide Impurity 15 (CAS 5054-59-1)
- Disperse Yellow 9 (CAS 6373-73-5)
- 3-Amino-5-nitro-4-phenoxybenzoic acid (CAS 35138-17-1)
- Crizotinib impurity 30 (CAS CATO-C4X-102530)
- Rifapentine Impurity 4 (CAS CATO-C4X-19594)
- Resmetirom impurity 78 (CAS CATO-C4X-291278)
- N-(2-Cyclopropoxy-3-(dimethylamino)phenyl)methanesulfonamide (CAS 1243447-13-3)
- 4-Hydroxyvaleric Acid Sodium Salt (CAS 56279-37-9)
- Lomefloxacin Impurity 6 (CAS CATO-C4X-20736)
- 5-(Pyridin-4-yl)-1-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (CAS 1326844-69-2)
- Diosmin EP Impurity A (CAS 6100-74-9)
- (S)-2-((tert-Butoxycarbonyl)amino)-4-cyclobutylbutanoic acid (CAS 2349835-19-2)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
Why CATO?
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