Leflunomide EP Impurity F CAS 1403564-06-6
| CAS No. | 1403564-06-6 |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 270.21 g/mol gives Leflunomide EP Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Leflunomide EP Impurity F (CAS 1403564-06-6), a pharmacopoeial impurity reference standard (molecular formula C12H9F3N2O2, MW 270.21 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Leflunomide EP Impurity F (C12H9F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Leflunomide Standards
- Leflunomide (CAS 75706-12-6)
- Leflunomide EP Impurity C (CAS 61643-23-0)
- Leflunomide EP Impurity E (CAS 208401-20-1)
- Leflunomide EP Impurity B (Teriflunomide) (CAS 163451-81-8)
- Leflunomide-d4 (CAS 1189987-23-2)
- Leflunomide EP Impurity B-d4 (Teriflunomide-d4) (CAS 1185240-22-5)
- Leflunomide Impurity 20 (CAS 2734292-21-6)
- Leflunomide Impurity 2 (CAS 827029-20-9)
Recommended Standards
- Teriflunomide Impurity 5 (CAS 220512-86-7)
- Teriflunomide Impurity 6 (CAS 62004-05-1)
- Nilotinib Impurity 16 (CAS 641571-13-3)
- Clenproperol-d7 (CAS 1173021-09-4)
- Carbetocin Impurity 42 (CAS CATO-C4X-191142)
- Relugolix Impurity 81 (CAS CATO-C4X-242981)
- Sitafloxacin impurity 72 (CAS CATO-C4X-115572)
- (S)-2-((S)-1-(2-(2-Aminoacetamido)acetyl)pyrrolidine-2-carboxamido)-5-guanidinopentanoic acid (CAS 506416-16-6)
- 2-((4-Fluorobenzyl)oxy)isoindoline-1,3-dione (CAS 76866-37-0)
- 8-Chlorothiazolo[5,4-g]quinazoline (CAS 171179-74-1)
- Nabumetone Impurity 2 (CAS 65726-24-1)
- Ethyl 6-((dimethylamino)methylene)-1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate (CAS 802541-49-7)
- N4,N4'-bis(2-ethyl-6-methylphenyl)-N4,N4'-bis(4-(4-methylstyryl)phenyl)-[1,1'-biphenyl]-4,4'-diamine (CAS 1874163-33-3)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com