Ethyl 5-Hydroxy-2-methyl-1H-indole-3-carboxylate CAS 7598-91-6
| CAS No. | 7598-91-6 |
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 5-Hydroxy-2-methyl-1H-indole-3-carboxylate (CAS 7598-91-6), molecular formula C12H13NO3 and molecular weight 219.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 5-Hydroxy-2-methyl-1H-indole-3-carboxylate (C12H13NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13NO3 |
| Molecular Weight | 219.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 3-hydroxy-5-methyl-1H-indole-2-carboxylate (CAS 1060803-17-9)
- 3-Hydroxy-1-isobutylpyrido[2,3-b]pyrazin-2(1H)-one (CAS 1443285-87-7)
- Ethyl 3-hydroxy-4-methyl-1H-indole-2-carboxylate (CAS 153501-38-3)
- 7-Hydroxy-3-methyl-1H,3H,3aH,4H,5H-[1,3]oxazolo[3,4-a]quinolin-1-one (CAS 1824633-17-1)
- (R)-2-(4-Hydroxy-2-butyl)isoindoline-1,3-dione (CAS 245728-73-8)
- (S)-2-(4-Hydroxy-2-butyl)isoindoline-1,3-dione (CAS 545376-10-1)
- 1-Ethyl-5-hydroxy-2-methyl-1h-indole-3-carboxylic acid (CAS 38189-61-6)
- 2-(1-Hydroxy-2-methylpropan-2-yl)-2,3-dihydro-1h-isoindole-1,3-dione (CAS 4490-74-8)
Recommended Standards
- Ethyl 5-amino-7-methylbenzofuran-2-carboxylate (CAS 791054-53-0)
- Ethyl 5-Methoxy-1H-indole-2-carboxylate (CAS 4792-58-9)
- Ethyl 5-amino-2-methylimidazo[1,2-a]pyridine-3-carboxylate (CAS 35220-24-7)
- Ethyl 5-Methoxyindole-3-carboxylate (CAS 59292-36-3)
- 6-Chloro-4-cyclopropylquinazolin-2-ol (CAS 150878-36-7)
- 3-[3-(difluoromethoxy)phenyl]-4-methyl-1h-pyrazol-5-amine (CAS 1187027-03-7)
- 2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylbutanoic acid (CAS 1214028-21-3)
- 2-(3,5-Dibromophenyl)-9-phenyl-9H-carbazole (CAS 1351692-34-6)
- Diethyl 4-oxocyclohexane-1,1-dicarboxylate (CAS 55704-60-4)
- 1-(5-Bromo-2-thienyl)ethanamine (CAS 129605-38-5)
- (1S)-1-[(2S)-pyrrolidin-2-yl]ethanol (CAS 113865-55-7)
- N-(4-Bromo-2-chlorophenyl)-4-chlorobenzamide (CAS 898648-07-2)
- 1-(4-bromo-3-methylphenyl)cyclohexane-1-carboxylic acid (CAS 1897181-62-2)
- 107444-51-9 0JS9125PIZ Glucagon-like peptide 1 (7-36) Glucagon-related peptide 1 (Rana catesbeiana), 3-L-glutamic acid-10-L-valine-16-glycine-17-L-glutamine-23-L-isoleucine-24-L-alanine-27-L-valine-30-L-argininamide-31-de-L-proline-32-de-L-lysine- Glp-I (7-36) Proglucagon (78-107) Human glucagon-like peptide-1-(7-36) amide Human GLP-1-(7-36)-amide Glucagon-like peptide-I(7-36) amide Rat GLP-I(7-36)amide Insulinotropin (human) MKC 253 UNII-0JS9125PIZ (CAS 107444-51-9)
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