Penicillin Impurity 40 CAS 76350-36-2
| CAS No. | 76350-36-2 |
| Molecular Formula | C8H10ClNO5S |
| Molecular Weight | 267.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Penicillin Impurity 40 (CAS 76350-36-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10ClNO5S and a molecular weight of 267.69 g/mol.
Structurally, Penicillin Impurity 40 (C8H10ClNO5S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 267.69 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10ClNO5S |
| Molecular Weight | 267.69 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Penicillin Standards
- Penicillin V (CAS 87-08-1)
- Penicillin V-d5 (CAS 1356837-87-0)
- Penicillin V methyl ester (CAS 2315-05-1)
- Penicillin V β-Sulfoxide-d (CAS 148680-07-3)
- Penicillin Impurity 5 (CAS 62730-81-8)
- Penicillin Impurity 42 (CAS CATO-C4X-189942)
- Penicillin-G 4-methoxybenzyl ester sulfoxide (CAS 30034-13-0)
- Penicillin G Clemizol (CAS 6011-39-8)
Recommended Standards
- 909421-69-8 (5-Chlorothiophen-2-yl)(4-nitrophenyl)methanone DTXSID90641820 (CAS 909421-69-8)
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- 2-chloro-N-[5-chloro-2-(4-ethoxyphenoxy)phenyl]acetamide (CAS 930395-63-4)
- 3-Chloro-5-methoxybenzo[b]thiophene-2-carbaldehyde (CAS 1315550-50-5)
- (1-[(tert-Butoxy)carbonyl]-6-cyano-1H-indol-3-yl)boronic acid (CAS 2304634-71-5)
- 5-Methyl-2-(3-nitrophenyl)-1H-1,2,4-triazol-3(2H)-one (CAS 97538-37-9)
- 1-(3-Methylphenyl)-3-(pyridin-3-yl)propan-2-one (CAS 1271080-79-5)
- 4-(Dimethylamino)-2-fluorobenzonitrile (CAS 1189353-13-6)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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