Tafamidis Impurity 2 CAS CATO-C4X-28772
| CAS No. | CATO-C4X-28772 |
| Molecular Formula | C21H11Cl4NO5 |
| Molecular Weight | 499.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tafamidis Impurity 2.
As a process- or degradation-related impurity, Tafamidis Impurity 2 (CAS CATO-C4X-28772, C21H11Cl4NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tafamidis Impurity 2 (C21H11Cl4NO5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 499.13 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H11Cl4NO5 |
| Molecular Weight | 499.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tafamidis Standards
- Tafamidis Impurity 12 (CAS CATO-C4X-287712)
- Tafamidis Impurity 5 (CAS CATO-C4X-28775)
- Tafamidis Impurity 7 (CAS CATO-C4X-28777)
- Tafamidis Impurity 13 (CAS CATO-C4X-287713)
- Tafamidis Impurity 1 (CAS 1184581-58-5)
- Tafamidis Impurity 3 (CAS 1183404-30-9)
- Tafamidis Impurity 9 (CAS 1395964-06-3)
- Tafamidis (CAS 594839-88-0)
Recommended Standards
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