Sitagliptin Impurity 4 CAS 764667-65-4
| CAS No. | 764667-65-4 |
| Molecular Formula | C16H12F6N4O2 |
| Molecular Weight | 406.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Sitagliptin Impurity 4 (CAS 764667-65-4), a pharmacopoeial impurity reference standard (molecular formula C16H12F6N4O2, MW 406.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Sitagliptin Impurity 4 (C16H12F6N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H12F6N4O2 |
| Molecular Weight | 406.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 108 (CAS CATO-C4X-1144108)
- Sitagliptin Impurity 109 (CAS CATO-C4X-1144109)
- Sitagliptin Impurity 137 (CAS CATO-C4X-1144137)
- Sitagliptin Impurity 23 (CAS CATO-C4X-114423)
- Sitagliptin Impurity 24 (CAS CATO-C4X-114424)
- Sitagliptin Impurity 9 (CAS 767340-03-4)
- Sitagliptin EP Impurity A (CAS 823817-55-6)
- Sitagliptin Impurity 116 (CAS 945261-50-7)
Recommended Standards
- Ruxolitinib Impurity 94 (CAS CATO-C4X-205894)
- 4-(2,4-Dichlorophenyl)-2-morpholino-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile (CAS 1202041-71-1)
- 3-(2-((3,4-Dichlorophenyl)amino)thiazol-5-yl)-3-oxo-N-phenylpropanamide (CAS 241132-49-0)
- 4-[(1E)-[(4-Chlorophenyl)imino]methyl]phenyl 4-chlorobenzene-1-sulfonate (CAS 331460-61-8)
- Barloxavir impurity 78 (CAS 3047099-98-6)
- Alectinib Impurity 49 (CAS CATO-C4X-283649)
- Oseltamivir Impurity 220 (CAS CATO-C4X-1720220)
- Tofacitinib Impurity 36 (CAS CATO-C4X-107936)
- 2-(3-Methoxypropyl)-3-oxoisoindoline-4-carboxylic acid (CAS 881041-34-5)
- 4-{[(2,5-dichlorophenyl)sulfanyl]methyl}benzoic acid (CAS 413582-76-0)
- 2-Chloro-5-(1-pyrrolidinylcarbonyl)benzenesulfonyl chloride (CAS 91193-66-7)
- 8-Chloroisoquinoline hydrochloride (CAS 61563-32-4)
- (2-Bromo-3-iodophenyl)methanamine (CAS 1261448-43-4)
- D-[His]1-Semaglutide X TFA salt (CAS CATO-CPTD788634)
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