Sitagliptin Impurity 52 CAS 764667-64-3
| CAS No. | 764667-64-3 |
| Molecular Formula | C14H11F3O5 |
| Molecular Weight | 316.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sitagliptin Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Sitagliptin Impurity 52 (CAS 764667-64-3), a pharmacopoeial impurity reference standard (molecular formula C14H11F3O5, MW 316.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Sitagliptin Impurity 52 (C14H11F3O5) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H11F3O5 |
| Molecular Weight | 316.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Sitagliptin Standards
- Sitagliptin Impurity 77 (CAS 1152439-73-0)
- Sitagliptin Impurity 3 (CAS 1824443-71-1)
- Sitagliptin Impurity 36 (CAS 851307-12-5)
- Sitagliptin Impurity 37 (CAS 486459-98-7)
- Sitagliptin Impurity 38 (CAS 269396-59-0)
- Sitagliptin Impurity 7 (CAS 767352-30-7)
- Sitagliptin Impurity 56 (CAS 1582-05-4)
- Sitagliptin Impurity 134 (CAS CATO-C4X-1144134)
Recommended Standards
- N-Benzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazol-2-amine (CAS 2096336-86-4)
- N-(3-bromo-4-ethoxy-5-methoxybenzyl)butan-2-amine (CAS 893577-03-2)
- Verapamil Impurity 18 (CAS 66618-12-0)
- 4-(Cyclopropylethynyl)-5,6-difluoro-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one (CAS 214287-71-5)
- Ceftazidime impurity 125 (CAS CATO-C4X-1212125)
- Clindamycin Impurity 56 (CAS CATO-C4X-134156)
- Safinamide Impurity 33 (CAS 405-85-6)
- 1-(2-(Diethylamino)ethyl)-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-(4-isopropoxy-3-methylbenzoyl)-1H-pyrrol-2(5H)-one (CAS 371233-37-3)
- Methyl 4-(3-(4-formylphenoxy)propoxy)benzoate (CAS 937602-00-1)
- 2,2-Dimethyl-3-(2-methylpropoxy)cyclobutan-1-one (CAS 2063-95-8)
- 6-(((2,5-Dimethoxyphenyl)amino)methyl)-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine (CAS 159210-76-1)
- Glycyanine (CAS 1562-85-2)
- (2E)-2-Pentylidene-2,3,4,9-tetrahydro-1H-carbazol-1-one (CAS 866149-30-6)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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