Ritonavir EP Impurity B CAS 765875-58-9
| CAS No. | 765875-58-9 |
| Molecular Formula | C28H36N4O4S |
| Molecular Weight | 524.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ritonavir EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Ritonavir EP Impurity B (CAS 765875-58-9), a pharmacopoeial impurity reference standard (molecular formula C28H36N4O4S, MW 524.67 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ritonavir EP Impurity B (C28H36N4O4S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H36N4O4S |
| Molecular Weight | 524.67 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ritonavir Standards
- Ritonavir EP Impurity J (CAS 162849-95-8)
- Ritonavir EP Impurity K (CAS 1010809-39-8)
- Ritonavir EP Impurity F (CAS 1010809-61-6)
- Ritonavir Impurity 61 (CAS CATO-C4X-175161)
- Ritonavir EP Impurity D (CAS 144142-33-6)
- Ritonavir EP Impurity H (CAS 1010809-43-4)
- Ritonavir EP Impurity C (CAS 1010808-43-1)
- Ritonavir Impurity 60 (CAS 2454100-44-6)
Recommended Standards
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Why CATO?
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