Phenylbutyrate Impurity 15 CAS 77063-20-8
| CAS No. | 77063-20-8 |
| Molecular Formula | C17H25Cl2NO2 |
| Molecular Weight | 346.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Phenylbutyrate Impurity 15 (CAS 77063-20-8, C17H25Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Phenylbutyrate Impurity 15 (C17H25Cl2NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 346.29 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H25Cl2NO2 |
| Molecular Weight | 346.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Phenylbutyrate Standards
- Phenylbutyrate Impurity 11 (CAS CATO-C4X-258311)
- Phenylbutyrate Impurity 12 (CAS CATO-C4X-258313)
- Phenylbutyrate Impurity 18 (CAS CATO-C4X-258318)
- Phenylbutyrate Impurity 7 (CAS 864811-35-8)
- Phenylbutyrate Impurity 8 (CAS 1443417-10-4)
- Phenylbutyrate Impurity 12 (CAS CATO-C4X-258312)
- Phenylbutyrate Impurity 9 (CAS 54698-75-8)
- Phenylbutyrate Impurity 16 (CAS CATO-C4X-258316)
Recommended Standards
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- Dapagliflozin Impurity 20 (CAS 2169998-23-4)
- Imeglimin Impurity 3 (CAS CATO-C4X-32753)
- Ipratropium Impurity 14 (CAS CATO-C4X-166514)
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- 3-Methoxy-1,2-Propanediol (CAS 623-39-2)
- Neuropeptide VF (124-131) (human) (CAS 311309-27-0)
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