Dapagliflozin Impurity 20 CAS 2169998-23-4
| CAS No. | 2169998-23-4 |
| Molecular Formula | C21H23ClO7 |
| Molecular Weight | 422.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 20 is closely related to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dapagliflozin Impurity 20 (CAS 2169998-23-4) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23ClO7 and a molecular weight of 422.86 g/mol.
Structurally, Dapagliflozin Impurity 20 (C21H23ClO7) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 422.86 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H23ClO7 |
| Molecular Weight | 422.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 171 (CAS CATO-C4X-1138171)
- Dapagliflozin Impurity 37 (CAS 946525-39-9)
- Dapagliflozin Impurity 109 (CAS 2088749-74-8)
- Dapagliflozin Impurity 110 (CAS CATO-C4X-1138110)
- Dapagliflozin Impurity 115 (CAS 1210040-47-3)
- Dapagliflozin Impurity 147 (CAS CATO-C4X-1138147)
- Dapagliflozin Impurity 19 (CAS 1204222-85-4)
- Dapagliflozin impurity 224 (CAS CATO-C4X-1138224)
Recommended Standards
- Lercanidipine Impurity 20 (CAS 890045-70-2)
- Amlodipine Impurity 56 (CAS 2418591-36-1)
- Lercanidipine Impurity 22 (CAS CATO-C4X-136422)
- Ethyl 3-{[(4-chlorophenyl)carbamoyl]methoxy}pyrido[1,2-a]indole-10-carboxylate (CAS 339107-06-1)
- Butylphthalide Impurity 17 (CAS 691863-84-0)
- Loratadine Impurity 49 (CAS CATO-C4X-142649)
- Gadodiamide Impurity 6 (CAS CATO-C4X-31436)
- 2-(4-Bromo-3-methylphenoxy)acetohydrazide (CAS 327070-44-0)
- (2-Chloro-4-methyloxazol-5-yl)methanamine (CAS 1260672-34-1)
- (4-((2-Acrylamidoethyl)carbamoyl)-3-fluorophenyl)boronic acid (CAS 1313712-90-1)
- 3-(((1,5-Dimethyl-1H-pyrazol-3-yl)amino)methyl)phenol hydrochloride (CAS 1856034-70-2)
- 4-[(3-Chloro-5-fluorophenyl)carbonyl]morpholine (CAS 1881292-79-0)
- (3-Ethyl-1,2,4-oxadiazol-5-yl)methanol (CAS 959237-62-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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