Metolazone CAS 17560-51-9
| CAS No. | 17560-51-9 |
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Metolazone.
CATO supplies Metolazone (CAS 17560-51-9), a certified reference material (molecular formula C16H16ClN3O3S, MW 365.83 g/mol) for analytical method development and quality control.
Metolazone (C16H16ClN3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Metolazone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.83 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Metolazone Standards
Recommended Standards
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- 5-Acetyl-6-aminonicotinaldehyde (CAS 1393554-26-1)
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- Gemcitabine Impurity 15 (Mixture of Diastereomers) (CAS CATO-C4X-137215)
- 4-[[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]amino]-4-oxo-butanoic acid (CAS 1488107-60-3)
- [5-(4-Chlorobenzenesulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 3,5-bis(trifluoromethyl)benzoate (CAS 318289-12-2)
- 1-(5-Chlorothiophen-2-yl)-2-methylpropan-2-ol (CAS 887576-13-8)
- N-(1,3-Dithiolan-2-ylidene)methanamine (CAS 1630-99-5)
- 2-(1H-Pyrrol-2-yl)-5,6-dihydro-2H-1,3-oxazine (CAS 750588-74-0)
- Insulin Degludec Impurity 3 (CAS CATO-C4X-21573)
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