Penfluridol Impurity 8 CAS 77294-14-5
| CAS No. | 77294-14-5 |
| Molecular Formula | C16H16ClFO |
| Molecular Weight | 278.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Penfluridol Impurity 8 (CAS 77294-14-5), a pharmacopoeial impurity reference standard (molecular formula C16H16ClFO, MW 278.75 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system, Penfluridol Impurity 8 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 278.75 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16ClFO |
| Molecular Weight | 278.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
Related Penfluridol Standards
- Penfluridol Impurity 11 (CAS CATO-C4X-353811)
- Penfluridol Impurity 1 (CAS 21928-50-7)
- Penfluridol Impurity 15 (CAS 94545-16-1)
- Penfluridol Impurity 10 (CAS 262272-58-2)
- Penfluridol Impurity 6 (CAS CATO-C4X-35386)
- Penfluridol Impurity 7 (CAS 1489363-63-4)
- Penfluridol Impurity 14 (CAS 106392-60-3)
- Penfluridol Impurity 1 (CAS 3799-84-6)
Recommended Standards
- N1-((4-chlorophenyl)(4-fluorophenyl)methyl)ethane-1,2-diamine (CAS 952958-84-8)
- 3-Amino-4-chloro-N-(3-methoxypropyl)-benzenesulfonamide (CAS 1094269-51-8)
- 5-Chloro-2-(2-methylphenyl)sulfanylbenzoic acid (CAS 93288-98-3)
- 4-Chloro-n-[2-(1h-pyrazol-1-yl)ethyl]-1,3-benzothiazol-2-amine (CAS 1177299-27-2)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Fluocinolone Acetonide Impurity 25 (CAS 156856-80-3)
- Etoricoxib Impurity 28 (CAS 5470-70-2)
- 5-(3-(Benzyloxy)-7-bromo-1-fluoronaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide (CAS 1227747-66-1)
- N-(3-(2-Methoxyethyl)-6-(methylsulfonyl)benzo[d]thiazol-2(3H)-ylidene)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide (CAS 864977-28-6)
- (S)-Dimethyl 2-phenylsuccinate (CAS 61548-76-3)
- 1-(4-Methoxyphenyl)-N3,N3-dimethylpropane-1,3-diamine (CAS 933723-78-5)
- 2-(1-(Tert-butoxycarbonyl)-2,2-dimethylpiperidin-4-yl)acetic acid (CAS 1780990-27-3)
- (Tetrahydro-2H-pyran-3-yl)methyl methanesulfonate (CAS 164523-24-4)
- Semaglutide impurity 194 (CAS CATO-C4X-2226194)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com