Coclaurine Impurity 3 HCl CAS 77354-33-7
| CAS No. | 77354-33-7 |
| Molecular Formula | C19H23NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Coclaurine Impurity 3 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Coclaurine Impurity 3 HCl (CAS 77354-33-7), a pharmacopoeial impurity reference standard (molecular formula C19H23NO3HCl, MW 349.85 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Coclaurine Impurity 3 HCl is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 349.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H23NO3 HCl |
| Molecular Weight | 349.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Coclaurine Standards
- Coclaurine Impurity 112 (CAS 116331-72-7)
- Coclaurine Impurity 2 HCl (CAS 13233-00-6)
- Coclaurine Related Compound 1 (CAS 138644-99-2)
- (±)-Coclaurine HCl (CAS 17934-80-4)
- (R)-Coclaurine HCl (CAS 19894-19-0)
- Coclaurine Impurity 113 (CAS 2158198-78-6(TFA Salt))
- Coclaurine Impurity 111 (CAS 2158201-34-2(TFA Salt))
- (+)-Coclaurine (CAS 2196-60-3)
Recommended Standards
- Minocycline impurity 74 (CAS 17779-50-9)
- Prednisone Impurity 7 (CAS CATO-C4X-16947)
- Digoxin EP Impurity F (CAS 5297-05-2)
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- Methyl 5-(p-tolyl)picolinate (CAS 1355246-89-7)
- (5-((Butylamino)methyl)thiophen-2-yl)boronic acid (CAS 919347-27-6)
- (S)-6-(Trifluoromethyl)chroman-4-amine hydrochloride (CAS 2088960-08-9)
- Ethoxydimethyl(3-(oxiran-2-ylmethoxy)propyl)silane (CAS 17963-04-1)
- 1-(3-Methoxyphenyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (CAS 1809876-45-6)
- Des-Val23-Tirzepatide (CAS CATO-CPTD788950)
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