Montelukast EP Impurity G CAS 774538-96-4
| CAS No. | 774538-96-4 |
| Molecular Formula | C35H36ClNO3S |
| Molecular Weight | 586.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 586.18 g/mol gives Montelukast EP Impurity G distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Montelukast EP Impurity G (CAS 774538-96-4), a pharmacopoeial impurity reference standard (molecular formula C35H36ClNO3S, MW 586.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Montelukast EP Impurity G (C35H36ClNO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 586.18 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Montelukast EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C35H36ClNO3S |
| Molecular Weight | 586.18 g/mol |
| Purity | >90.0% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Montelukast Standards
- Montelukast (CAS 158966-92-8)
- Montelukast EP Impurity A (CAS 220927-27-5)
- Montelukast EP Impurity H (CAS 851755-56-1)
- Montelukast Impurity 24 (CAS CATO-C4X-103124)
- Montelukast Amide (CAS 866923-63-9)
- Montelukast Impurity 2 (CAS CATO-C4X-10312)
- Montelukast Impurity N1 (CAS 162489-70-5)
- Montelukast Impurity 21 (CAS 142147-67-9)
Recommended Standards
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