2-Chloroquinoline-6-carbonitrile CAS 78060-54-5
| CAS No. | 78060-54-5 |
| Molecular Formula | C10H5ClN2 |
| Molecular Weight | 188.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Chloroquinoline-6-carbonitrile (CAS 78060-54-5) is a high-purity analytical reference standard with the molecular formula C10H5ClN2 and a molecular weight of 188.61 g/mol.
The molecular framework of 2-Chloroquinoline-6-carbonitrile (C10H5ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H5ClN2 |
| Molecular Weight | 188.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroquinoline Standards
- 2-Chloroquinoline-5-carbonitrile (CAS 1231761-06-0)
- 2-Chloroquinoline-8-carbonitrile (CAS 1231761-07-1)
- 8-Chloroquinoline-2-carbonitrile (CAS 1231761-08-2)
- 5-Chloroquinoline-4-carbonitrile (CAS 1231761-11-7)
- 8-Chloroquinoline-5-carbonitrile (CAS 1256463-59-8)
- 5-Chloroquinoline-7-carbonitrile (CAS 1256463-65-6)
- 4-Chloroquinoline-8-carbonitrile (CAS 132664-45-0)
- 7-Chloroquinoline-4-carbonitrile (CAS 13337-75-2)
Recommended Standards
- 2-Chloroquinoline-4-carbonitrile (CAS 4366-88-5)
- 3-(2-Chloroethyl)-6-methylpyrimidine-2,4(1H,3H)-dione (CAS 22359-13-3)
- 2-Chloroquinoline-3-carbonitrile (CAS 95104-21-5)
- 3-(4-Chloro-1H-pyrazol-1-yl)-2-methylpropanoic acid (CAS 957301-84-7)
- 4-Methyl-2H-pyran-2-one (CAS 22682-12-8)
- 2-(Azetidin-3-ylmethyl)pyrimidine (CAS 1236862-58-0)
- 4-(Hexyloxy)-3-methoxybenzaldehyde (CAS 61096-84-2)
- Glucose Impurity N3 (CAS 23147-58-2)
- 3-fluoroadamantan-1-amine hydrochloride (CAS 120350-83-6)
- 4-Cyclopropoxy-5-iodo-2-nitropyridine (CAS 1243325-96-3)
- Tert-butyl 3-(4-bromophenyl)-3-((tert-butylsulfinyl)amino)azetidine-1-carboxylate (CAS 1313872-55-7)
- N-(piperidin-1-yl)pyrimidin-2-amine (CAS 864434-19-5)
- 4-Chloro-2-(3-chlorophenyl)-5-hydroxypyridazin-3(2H)-one (CAS 336109-39-8)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
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