trans-2-(Trifluoromethyl)cyclopropanecarboxylic Acid CAS 78376-99-5
| CAS No. | 78376-99-5 |
| Molecular Formula | C5H5F3O2 |
| Molecular Weight | 154.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of trans-2-(Trifluoromethyl)cyclopropanecarboxylic Acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
trans-2-(Trifluoromethyl)cyclopropanecarboxylic Acid (CAS 78376-99-5) is a high-purity analytical reference standard with the molecular formula C5H5F3O2 and a molecular weight of 154.09 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, trans-2-(Trifluoromethyl)cyclopropanecarboxylic Acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 154.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), trans-2-(Trifluoromethyl)cyclopropanecarboxylic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F3O2 |
| Molecular Weight | 154.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related trans Standards
- 4-(Trifluoromethyl)-4,5-dihydrooxazol-2-amine (CAS 1337881-82-9)
- 5-(Trifluoromethyl)dihydrofuran-2(3H)-one (CAS 1547-45-1)
- 4-(Trifluoromethyl)imidazolidin-2-one (CAS 1694615-69-4)
- 3-(Trifluoromethyl)oxolan-2-one (CAS 174744-18-4)
- 1-(Trifluoromethyl)cyclopropanecarboxylic Acid (CAS 277756-46-4)
- 2-(Trifluoromethyl)cyclopropane-1-carboxylic acid (CAS 22581-33-5)
- 2-(trifluoromethyl)-2-propenoic acid methyl ester 382-90-1 A824092 methyl 2-(trifluoromethyl)prop-2-enoate (CAS 382-90-1)
- (R)-2-Trifluoromethyl-piperazine (CAS 1187928-91-1)
Recommended Standards
- Allyl trifluoroacetate (CAS 383-67-5)
- 1,1,1-Trifluoroacetylacetone 367-57-7 (2,2,2-TRIFLUOROACETYL)ACETONE;1,1,1-TRIFLUORO-2,4-PENTANEDIONE;1,1,1-TRIFLUOROACETYLACETONE;1,1,1-TRIFLUOROPENTANE-2,4-DIONE;2,4-PENTANEDIONE, 1,1,1-TRIFLUORO-;A,A,A-TRIFLUOROACETYLACETONE;ACETYL TRIFLUOROACETONE;ALPHA,ALPHA,ALPHA-TRIFLUOROACETYLACETONE;TAA;TFPD-H;TRIFLUOROACETYLACETONE SC11824 (CAS 367-57-7)
- 3-Hydroxy-5-(trifluoromethyl)pyrazole (CAS 76480-99-4)
- 3,3,3-Trifluoroprop-1-en-2-yl acetate (CAS 2247-91-8)
- 1-(4-{[4-(ethylamino)pyridin-2-yl]methyl}piperazin-1-yl)ethan-1-one (CAS 1423032-02-3)
- 3-Amino-N-(3,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 625370-26-5)
- (1-(Tert-butyl)-1H-pyrazol-4-yl)(2-((3-methylbenzyl)oxy)phenyl)methanone (CAS 955975-74-3)
- 3-Azetidinomethyl-4-trifluoromethylbenzophenone (CAS 898771-95-4)
- Posaconazole impurity 210 (CAS CATO-C4X-1208210)
- Rifampicin-d3 (CAS 1262052-36-7)
- YM-201636 (CAS 371942-69-7)
- 8-Carbamoyl-2-(furan-2-yl)imidazo[1,5-a]pyrimidine-4-carboxylic acid (CAS 924047-54-1)
- 6-(1H-Imidazol-2-yl)picolinonitrile (CAS 840488-50-8)
- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com