Guanfacine Hydrochloride Impurity 2 CAS 78433-88-2
| CAS No. | 78433-88-2 |
| Molecular Formula | C8H7Cl2NO |
| Molecular Weight | 204.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H7Cl2NO, Guanfacine Hydrochloride Impurity 2 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 204.05 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Guanfacine Hydrochloride Impurity 2 (CAS 78433-88-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7Cl2NO and a molecular weight of 204.05 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2NO |
| Molecular Weight | 204.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Guanfacine Standards
- Guanfacine Hydrochloride Impurity 3 (CAS 6575-24-2)
- Guanfacine Hydrochloride Impurity 4 (CAS 57486-36-9)
- Guanfacine Hydrochloride Impurity 1 (CAS 54551-83-6)
- Guanfacine Impurity 13 (CAS 130974-86-6)
- Guanfacine Impurity 10 (CAS 24067-37-6)
- Guanfacine Impurity 6 (CAS 90793-64-9)
- Guanfacine Impurity 4 (CAS 78622-22-7)
- Guanfacine-13C,15N3 (CAS 1189924-28-4)
Recommended Standards
- Tranexamic Impurity 21 (CAS 195370-52-6)
- Clenbuterol EP impurity C (CAS 37148-48-4)
- Diclofenac impurity 7 (CAS 2563-99-7)
- Aripiprazole Impurity N16 (CAS 1260893-49-9)
- Ramelteon Impurity 39 (CAS CATO-C4X-262239)
- Cetirizine impurity N1 (CAS 58023-19-1)
- Trazodone Impurity 43 (CAS CATO-C4X-177243)
- 6'-Bromospiro[cyclobutane-1,2'-thiochroman]-4'-one 1',1'-dioxide (CAS 2198098-45-0)
- 2-Hydroxy-2-(4-(trifluoromethoxy)phenyl)acetic acid (CAS 886762-51-2)
- 3-(Cyclopropylamino)propanenitrile (CAS 58196-47-7)
- 5-Bromo-2-(2-methoxyphenyl)-N,N-dimethylpyrimidin-4-amine (CAS 823796-54-9)
- Furan-3-yl(naphthalen-1-yl)methanol (CAS 1016925-55-5)
- 5-(Cyclopropylsulfonyl)-1H-imidazole (CAS 1514898-30-6)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
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