Guanfacine Hydrochloride Impurity 3 CAS 6575-24-2
| CAS No. | 6575-24-2 |
| Molecular Formula | C8H6Cl2O2 |
| Molecular Weight | 205.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Guanfacine Hydrochloride Impurity 3 (C8H6Cl2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Guanfacine Hydrochloride Impurity 3 (CAS 6575-24-2), a pharmacopoeial impurity reference standard (molecular formula C8H6Cl2O2, MW 205.04 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6Cl2O2 |
| Molecular Weight | 205.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Guanfacine Standards
- Guanfacine Hydrochloride Impurity 2 (CAS 78433-88-2)
- Guanfacine Hydrochloride Impurity 4 (CAS 57486-36-9)
- Guanfacine Hydrochloride Impurity 1 (CAS 54551-83-6)
- Guanfacine Impurity 13 (CAS 130974-86-6)
- Guanfacine Impurity 10 (CAS 24067-37-6)
- Guanfacine Impurity 6 (CAS 90793-64-9)
- Guanfacine Impurity 4 (CAS 78622-22-7)
- Guanfacine-13C,15N3 (CAS 1189924-28-4)
Recommended Standards
- Tranexamic Impurity 19 (CAS 5278-91-1)
- Revefenacin Impurity 113 (CAS 1379371-59-1)
- Econazole Impurity 4 (CAS 137958-96-4)
- Revefenacin impurity 94 (CAS CATO-C4X-203194)
- Parecoxib sodium Impurity 18 (CAS 181696-73-1)
- Dyclonine Impurity 25 (CAS CATO-C4X-188125)
- LCZ-696 Impurity 53 (CAS CATO-C4X-169653)
- Ponatinib Impurity 40 (CAS CATO-C4X-226940)
- (2-Oxoindoline-3,3-diyl)bis(4,1-phenylene) dicyclohexanecarboxylate (CAS CATO-LCAD304282)
- 4,4,5,5-Tetramethyl-2-(4-(2-(methylsulfonyl)ethyl)phenyl)-1,3,2-dioxaborolane (CAS 936728-14-2)
- 1-Ethoxy-1,3,3-Trimethoxypropane (CAS 123-59-1)
- 3-Methylisoquinolin-5-amine (CAS 54410-17-2)
- 1-(4-Bromo-3-methylphenyl)-6-chlorohexan-1-one (CAS 898760-96-8)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com