Azelastine hydrochloride CAS 79307-93-0
| CAS No. | 79307-93-0 |
| Molecular Formula | C22H24ClN3O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Azelastine hydrochloride.
Azelastine hydrochloride (CAS 79307-93-0), molecular formula C22H24ClN3OHCl and molecular weight 418.36 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Azelastine hydrochloride (C22H24ClN3OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 418.36 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Azelastine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24ClN3O HCl |
| Molecular Weight | 418.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Azelastine Standards
- Azelastine EP Impurity E (Z-Isomer) (CAS 105279-16-1)
- Azelastine Impurity 46 (CAS 109386-70-1)
- Azelastine EP Impurity B (CAS 110406-94-5)
- Azelastine Impurity 52 (CAS 1107016-94-3)
- Azelastine USP RC B HCI (CAS 117078-69-0)
- Azelastine Impurity 30 (CAS 117078-70-3)
- Azelastine-13C,d3 (CAS 1217019-80-1)
- Azelastine Impurity 17 (CAS 1239312-56-1)
Recommended Standards
- 4-isothiocyanato-1,5-dimethyl-1H-pyrazole (CAS 1001500-56-6)
- ethyl 5-chloro-7-oxo-4H-pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 2394830-31-8)
- tert-Butyl 3-(bromomethyl)-5-chloro-1H-indole-1-carboxylate (CAS 168143-76-8)
- tert-Butyl 6-(benzyloxy)-3-formyl-1H-indole-1-carboxylate (CAS 630110-71-3)
- 3-(Difluoromethyl)-5-fluorothieno[3,2-b]thiophene-2-carbaldehyde (CAS 2573123-04-1)
- 1-Acetylpyrazole-4-boronic Acid (CAS 1370366-65-6)
- 3-Cyclopropoxy-5-nitrobenzonitrile (CAS 1243406-96-3)
- 2,2,2-Trifluoro-1-(4-isobutylphenyl)ethanol (CAS 118453-45-5)
- Methyl (R)-3-amino-3-(4-bromo-3-methylphenyl)propanoate (CAS 1213481-58-3)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
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