Cyclosporin Impurity 16 CAS 79309-68-5
| CAS No. | 79309-68-5 |
| Molecular Formula | C12H25BO2Si |
| Molecular Weight | 240.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cyclosporin Impurity 16 (CAS 79309-68-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H25BO2Si and a molecular weight of 240.22 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, Cyclosporin Impurity 16 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 240.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H25BO2Si |
| Molecular Weight | 240.22 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 0.5 |
| CAS Registry Year (est.) | 1979 |
Related Cyclosporin Standards
- Cyclosporin Impurity N33 (CAS 59865-23-5)
- Cyclosporin L Related Compound 4 (CAS 81135-57-1)
- Cyclosporin Impurity 6 (CAS 1357559-51-3)
- Cyclosporin Impurity 18 (CAS CATO-C4X-131118)
- Iso Cyclosporin H TFA Salt (CAS 83602-43-1 (free amine))
- Cyclosporin Impurity 19 (CAS 2715287-08-2)
- Cyclosporin Impurity 15 (CAS 1907654-63-0)
- Cyclosporin A-Derivative 2 (CAS 156047-45-9)
Recommended Standards
- 1-(2,4-dimethoxyphenyl)-2,2,2-trifluoroethanone 1-(2,4-dimethoxyphenyl)-2,2,2-tris(fluoranyl)ethanone 578-16-5 A831619 (CAS 578-16-5)
- Doxofylline Impurity 28 (CAS 62637-09-6)
- 20445-31-2 27O5L9T1WM alpha-Methoxy-alpha-trifluoromethylphenylacetic acid, (+)- (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid EINECS 243-829-5 UNII-27O5L9T1WM (CAS 20445-31-2)
- Doxofylline Impurity 31 (CAS CATO-C4X-151331)
- Tofacitinib Impurity 116 (CAS 77862-24-9)
- Lenacapavir Impurity 29 (CAS CATO-C4X-324829)
- Avanafil Impurity 76 (CAS CATO-C4X-111876)
- 5-Amino-2-bromobenzaldehyde (CAS 1261565-91-6)
- N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine (CAS 100496-03-5)
- (5-Amino-4-carboxy-1H-pyrazol-1-yl)benzene 5-Amino-4-carboxy-1-phenyl-1H-pyrazole 5-amino-1-phenylpyrazole-4-carboxylic acid 51649-80-0 (CAS 51649-80-0)
- 2,8-Dichloro-6,7-dimethoxyquinazolin-4-amine (CAS 79572-01-3)
- 4-(o-Tolyl)-1H-pyrazol-3-amine hydrochloride (CAS 1028449-23-1)
- Methyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate (CAS 696631-99-9)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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