Vigabatrin Impurity 16 HCl CAS 794466-81-2(free base)
| CAS No. | 794466-81-2(free base) |
| Molecular Formula | C12H20N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vigabatrin Impurity 16 HCl (C12H20N2O3HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Vigabatrin Impurity 16 HCl (CAS 794466-81-2(free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C12H20N2O3HCl and a molecular weight of 276.76 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20N2O3 HCl |
| Molecular Weight | 276.76 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Vigabatrin Standards
- rac-Vigabatrin-13C,d2 (Major) (CAS 1330171-61-3)
- Vigabatrin EP Impurity E (CAS 1378466-25-1)
- Vigabatrin Impurity B HCl (CAS 1379403-11-8)
- Vigabatrin HCl (CAS 1391054-02-6)
- Vigabatrin Impurity 13 (CAS 1824506-31-1)
- Vigabatrin Impurity 20 TFA Salt (CAS 213758-47-5(free base))
- Vigabatrin Impurity 17 HCl (CAS 213758-47-5（free base）)
- Vigabatrin Impurity 5 (CAS 2324151-81-5)
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- Glycopyrrolate Impurity 3 (CAS 92021-41-5)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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