Indometacin Impurity 24 CAS 99508-25-5
| CAS No. | 99508-25-5 |
| Molecular Formula | C14H9Cl3O2 |
| Molecular Weight | 315.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Indometacin Impurity 24 (C14H9Cl3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Indometacin Impurity 24 (CAS 99508-25-5), a pharmacopoeial impurity reference standard (molecular formula C14H9Cl3O2, MW 315.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Indometacin Impurity 24 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl3O2 |
| Molecular Weight | 315.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related Indometacin Standards
- Indometacin Impurity 50 (CAS CATO-C4X-147050)
- Indometacin Impurity 51 (CAS CATO-C4X-147051)
- Indometacin Impurity 29 (CAS CATO-C4X-147029)
- Indometacin Impurity 59 (CAS CATO-C4X-147059)
- Indometacin Impurity 18 (CAS 75511-23-8)
- Indometacin Impurity 48 (CAS CATO-C4X-147048)
- Indometacin Impurity 49 (CAS CATO-C4X-147049)
- Indometacin Impurity 52 (CAS CATO-C4X-147052)
Recommended Standards
- N-(3-Amino-4-chlorophenyl)-3,5-dichlorobenzamide (CAS 926238-20-2)
- Ketoconazole Impurity 22 (CAS CATO-C4X-147222)
- N-(3-Amino-4-chlorophenyl)-2,4-dichlorobenzamide (CAS 926242-00-4)
- Ketoconazole Impurity 25 (CAS CATO-C4X-147225)
- Erlotinib Impurity 110 (CAS 2204518-92-1)
- Remdesivir Impurity 44 (CAS 1187550-21-5)
- Pseudoephedrine Impurity N8 (CAS 67844-52-4)
- Nintedanib Impurity 185 (CAS 652140-07-3)
- Tert-butyl 1-methyl-1H-imidazole-5-carboxylate (CAS 293733-51-4)
- 4-Amino-1-(benzyloxy)butan-2-ol (CAS 166746-63-0)
- 4-(4-Bromo-2-chlorophenoxy)piperidinehydrochloride (CAS 1219960-48-1)
- (2R,3S)-Methyl 2-amino-3-hydroxybutanoate (CAS 82679-55-8)
- 1-Bromo-1-cyano-3,3-dimethylbutan-2-one (CAS 89563-44-0)
- Acetyl Hexapeptide-38 (CAS 1400634-44-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com