Sertraline EP Impurity A HCl (rac-trans-Sertraline HCl) CAS 79617-99-5
| CAS No. | 79617-99-5 |
| Molecular Formula | C17H17Cl2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Sertraline EP Impurity A HCl (rac-trans-Sertraline HCl) (CAS 79617-99-5, C17H17Cl2NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sertraline EP Impurity A HCl (rac-trans-Sertraline HCl) (C17H17Cl2NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 342.69 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H17Cl2N HCl |
| Molecular Weight | 342.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline - Impurity C (Freebase) (CAS 107538-91-0)
- Sertraline Acetamide (CAS 1097616-52-8)
- Sertraline Carbamoyl Glucuronide (CAS 119733-44-7)
- Sertraline Impurity 26 (CAS 1198115-10-4（free base）)
- Sertraline RC 11 (CAS 1217630-23-3)
- Sertraline-d3 Hydrochloride (CAS 1217741-83-7)
- Sertraline Impurity 50 HCl (CAS 122873-20-5 (free base))
- Sertraline EP Impurity F Enantiomer (CAS 124379-29-9)
Recommended Standards
- Fluvoxamine EP Impurity J (CAS 1217241-15-0)
- Captopril EP Impurity M (CAS 83326-98-1)
- Pantoprazole Impurity 49 (CAS 1261238-06-5)
- N-Methyl-4-[2-(pyridin-4-yl)-1,3-thiazol-5-yl]pyrimidin-2-amine (CAS 1881321-44-3)
- 3,5-Difluorobenzohydrazide (CAS 244022-63-7)
- Glycolic acid-<SUP>13</SUP>C<SUB>2</SUB> (CAS 111389-68-5)
- Ethyl 7-(3,4-dimethoxyphenyl)-2-methyl-4-(4-methyl-3-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 503591-61-5)
- 8-Hydroxy Loxapine (CAS 61443-77-4)
- 3-Acetylpyridine hypoxanthine dinucleotide (CAS 4002-09-9)
- D-[Arg]30-Semaglutide (CAS CATO-C4X-222653)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com