Tenofovir disoproxil Impurity 88 CAS 80-40-0
| CAS No. | 80-40-0 |
| Molecular Formula | C9H12O3S |
| Molecular Weight | 200.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tenofovir disoproxil Impurity 88.
As a process- or degradation-related impurity, Tenofovir disoproxil Impurity 88 (CAS 80-40-0, C9H12O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Tenofovir disoproxil Impurity 88 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 200.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H12O3S |
| Molecular Weight | 200.25 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Sulfur Atoms | 1 |
Related Tenofovir Standards
- Tenofovir alafenamide impurity N1 (CAS 16958-60-4)
- Tenofovir Impurity 110 (CAS 20776-34-5)
- Tenofovir Impurity 24 (CAS 14047-28-0)
- Tenofovir Disoproxil Impurity 35 (CAS 14047-27-9)
- Tenofovir disoproxil Impurity 41 (CAS 1244022-52-3)
- Tenofovir Impurity 66 (CAS 36817-69-3)
- Tenofovir Impurity 67 (CAS 182626-47-7)
- Tenofovir Impurity 77 (CAS 1643116-22-6)
Recommended Standards
- Vortioxetine Impurity 116 (CAS 102439-46-3)
- Cephalexin Impurity 33 (CAS 883835-57-2)
- Propyl benzenesulfonate (CAS 80-42-2)
- Flurbiprofen Impurity 12 (CAS 55258-76-9)
- Suvorexant Impurity 43 (CAS 1234707-20-0)
- Ruxolitinib Impurity N7 (Mixture of Diastereomers) (CAS 1092973-95-9)
- Papaverine impurity 25 (CAS 33520-96-6)
- Tert-butyl 4-(3-methylpyridin-2-yl)-1,4-diazepane-1-carboxylate (CAS 946386-09-0)
- N'-((6-(4-Chlorophenoxy)pyrimidin-4-yl)thio)acetohydrazide (CAS 137927-75-4)
- 3,6-Dibromo-2-chloroquinoline (CAS 1379338-22-3)
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-(4-chlorobenzyl)-2-methyl-1H-indole (CAS 400074-09-1)
- (S)-6,7-Dihydro-5H-indeno[5,6-d][1,3]dioxol-5-amine (CAS 1259815-42-3)
- β-4,5-dibenzoyl-2-cyano- D-deoxyribrate (CAS 170983-98-9)
- D-β-Asp15-Tirzepatide (CAS CATO-CPTD788930)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com