Bupropion impurity 66 CAS 80478-42-8

Description

Compared with other compounds in its class, the molecular weight of 278.22 g/mol gives Bupropion impurity 66 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Bupropion impurity 66 (CAS 80478-42-8) is a certified pharmaceutical impurity reference standard with the molecular formula C13H20ClNOHCl and a molecular weight of 278.22 g/mol.

The molecular framework of Bupropion impurity 66 (C13H20ClNOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

CATO manufactures Bupropion impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

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