Acetazolamide EP Impurity F CAS 80495-47-2
| CAS No. | 80495-47-2 |
| Molecular Formula | C8H9N7O6S4 |
| Molecular Weight | 427.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 427.46 g/mol gives Acetazolamide EP Impurity F distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Acetazolamide EP Impurity F (CAS 80495-47-2), a pharmacopoeial impurity reference standard (molecular formula C8H9N7O6S4, MW 427.46 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Acetazolamide EP Impurity F (C8H9N7O6S4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 427.46 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Acetazolamide EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9N7O6S4 |
| Molecular Weight | 427.46 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 4 |
Related Acetazolamide Standards
- Acetazolamide Impurity 10 (CAS 32873-57-7)
- Acetazolamide-d3 (CAS 1189904-01-5)
- Acetazolamide EP Impurity E (CAS 827026-60-8)
- Acetazolamide (CAS 59-66-5)
- Acetazolamide EP Impurity D (CAS 14949-00-9)
- Acetazolamide Impurity 8 (CAS 4454-63-1)
- Acetazolamide EP Impurity A (CAS 60320-32-3)
- Acetazolamide EP Impurity C (CAS 32873-56-6)
Recommended Standards
- Cefpodoxime acid 7S isomer (CAS CATO-C4X-157967)
- N-[4-(2-Methoxyphenoxy)phenylsulfonyl]-DL-phenylalanine (CAS 1008961-78-1)
- Cefpodoxime Impurity 57 (CAS CATO-C4X-157957)
- 5-Methyl-4-(4-(morpholinosulfonyl)benzoyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (CAS 1021108-11-1)
- Enzalutamide Impurity 38 (CAS 948294-47-1)
- Topiroxostat Impurity 58 (CAS CATO-C4X-105558)
- Cetirizine Dihydrochloride EP Impurity B (CAS 942193-17-1)
- 1-Propylpyridinium Chloride (CAS 23271-47-8)
- 1-(5-Aminopyridin-2-yl)ethan-1-one (CAS 51460-32-3)
- N-hydroxy-2-[(4-hydroxy-1-piperidyl)methyl]benzamidine (CAS 1016879-10-9)
- 4-[(1E)-3-(Naphthalen-2-yl)-3-oxoprop-1-en-1-yl]phenyl 4-chlorobenzene-1-sulfonate (CAS 331460-96-9)
- 3-(4-(4-Chlorobenzyl)piperazin-1-yl)propanoic acid (CAS 874814-58-1)
- GinkgolideJ (CAS 107438-79-9)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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