Dotinurad Impurity 85 CAS 80547-63-3
| CAS No. | 80547-63-3 |
| Molecular Formula | C8H7ClO4 |
| Molecular Weight | 202.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dotinurad Impurity 85 (CAS 80547-63-3, C8H7ClO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dotinurad Impurity 85 (C8H7ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 202.59 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dotinurad Impurity 85 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO4 |
| Molecular Weight | 202.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | ＞95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
Related Dotinurad Standards
- Dotinurad Impurity 193 (CAS CATO-C4X-2494193)
- Dotinurad Impurity 170 (CAS 50910-60-6)
- Dotinurad Impurity 67 (CAS 39884-80-5)
- Dotinurad Impurity 77 (CAS 35458-33-4)
- Dotinurad Impurity 257 (CAS CATO-C4X-2494257)
- Dotinurad Impurity 98 (CAS CATO-C4X-249498)
- Dotinurad Impurity 99 (CAS CATO-C4X-249499)
- Dotinurad Impurity 211 (CAS 70679-89-9)
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