Ranitidine Impurity 20 CAS 82301-45-9

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.82301-45-9
Molecular FormulaC8H12ClNO
Molecular Weight173.64 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Ranitidine Impurity 20 CAS 82301-45-9 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 173.64 g/mol gives Ranitidine Impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Ranitidine Impurity 20 (CAS 82301-45-9), a pharmacopoeial impurity reference standard (molecular formula C8H12ClNO, MW 173.64 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Ranitidine Impurity 20 (C8H12ClNO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC8H12ClNO
Molecular Weight173.64 g/mol
AppearanceWhite to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1980
Halogen ContentCl-containing
Nitrogen Atoms1

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