Dexamethasone EP Impurity I CAS 14622-47-0
| CAS No. | 14622-47-0 |
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dexamethasone EP Impurity I is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dexamethasone EP Impurity I (CAS 14622-47-0, C22H28O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dexamethasone EP Impurity I (C22H28O5) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Dexamethasone Standards
- Dexamethasone EP Impurity J (CAS 2036-77-3)
- Dexamethasone EP Impurity D (CAS 24916-90-3)
- Dexamethasone impurity 70 (CAS CATO-C4X-116570)
- Dexamethasone impurity 91 (CAS CATO-C4X-116591)
- Dexamethasone Oxetanone (CAS 4089-36-5)
- Dexamethasone Impurity 104 (CAS 62800-49-1)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Dexamethasone Impurity 23 (CAS 59860-99-0)
Recommended Standards
- Bisoprolol Impurity 89 (CAS 2417155-12-3)
- Betamethasone EP Impurity E (CAS 981-34-0)
- Lubiprostone Impurity 44 (CAS CATO-C4X-113644)
- Betamethasone Impurity 120 (CAS 82536-56-9)
- Sunitinib Impurity 63 (CAS 2343-22-8)
- Cefazolin EP Impurity G (CAS 1172998-53-6)
- Trimebutine Impurity 10 (CAS CATO-C4X-185810)
- 5-Bromo-4-cyclopropoxypyridin-3-amine (CAS 1243321-74-5)
- Methyl 2-((5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetate (CAS 36244-28-7)
- 2-(4-(Trifluoromethyl)phenyl)benzo[d]thiazole (CAS 134384-31-9)
- 2-(2-Methyl-1,3-benzoxazol-5-yl)acetic acid (CAS 38196-01-9)
- 2-Chloro-1-(3,4-dimethylphenyl)ethan-1-one (CAS 50690-08-9)
- n-(Cyclohexylmethyl)benzenesulfonamide (CAS 26914-53-4)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
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