Nafamostat impurity 84 CAS 82955-97-3
| CAS No. | 82955-97-3 |
| Molecular Formula | C18H15N3O2 |
| Molecular Weight | 305.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nafamostat impurity 84 (CAS 82955-97-3, C18H15N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nafamostat impurity 84 (C18H15N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nafamostat impurity 84 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15N3O2 |
| Molecular Weight | 305.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 3 |
Related Nafamostat Standards
- Nafamostat impurity 82 (CAS CATO-C4X-133282)
- Nafamostat impurity 83 (CAS CATO-C4X-133283)
- Nafamostat Impurity 128 (CAS CATO-C4X-1332128)
- Nafamostat Impurity 53 (CAS CATO-C4X-133253)
- Nafamostat impurity 73 (CAS CATO-C4X-133273)
- Nafamostat impurity 130 (CAS CATO-C4X-1332130)
- Nafamostat impurity 115 (CAS CATO-C4X-1332115)
- Nafamostat Impurity N3 (CAS 115325-88-7)
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