Nafamostat impurity 73 CAS CATO-C4X-133273
| CAS No. | CATO-C4X-133273 |
| Molecular Formula | C15H14N4O3 |
| Molecular Weight | 298.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nafamostat impurity 73 (C15H14N4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Nafamostat impurity 73 (CAS CATO-C4X-133273, C15H14N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H14N4O3 |
| Molecular Weight | 298.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Nafamostat Standards
- Nafamostat Impurity 128 (CAS CATO-C4X-1332128)
- Nafamostat Impurity 53 (CAS CATO-C4X-133253)
- Nafamostat impurity 82 (CAS CATO-C4X-133282)
- Nafamostat impurity 83 (CAS CATO-C4X-133283)
- Nafamostat impurity 84 (CAS 82955-97-3)
- Nafamostat impurity 130 (CAS CATO-C4X-1332130)
- Nafamostat impurity 115 (CAS CATO-C4X-1332115)
- Nafamostat Impurity N3 (CAS 115325-88-7)
Recommended Standards
- Doxofylline Impurity 21 (CAS CATO-C4X-151321)
- Pemetrexed Impurity 49 (CAS CATO-C4X-172649)
- Levosimendan Impurity 67 (CAS CATO-C4X-130867)
- Pemetrexed Impurity 50 (CAS CATO-C4X-172650)
- Empagliflozin Impurity 73 (CAS CATO-C4X-106573)
- Tenofovir Alafenamide Impurity 27 HCl (CAS 431949-21-2(Free))
- Ambroxol Impurity 43 (CAS 529-23-7)
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- 5-(2-((tert-Butyldimethylsilyl)oxy)ethyl)oxazolidin-2-one (CAS 1184303-40-9)
- (S)-5-Methyl-1,3-dioxolane-2,4-dione (CAS 5997-42-2)
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- Nordeprenyl-d5 (CAS 1189725-08-3)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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