Phenylephrine impurity 94 CAS 83070-12-6
| CAS No. | 83070-12-6 |
| Molecular Formula | C9H8BrNO2 |
| Molecular Weight | 242.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 242.07 g/mol gives Phenylephrine impurity 94 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Phenylephrine impurity 94 (CAS 83070-12-6) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8BrNO2 and a molecular weight of 242.07 g/mol.
The molecular framework of Phenylephrine impurity 94 (C9H8BrNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Phenylephrine impurity 94 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8BrNO2 |
| Molecular Weight | 242.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Phenylephrine Standards
- Phenylephrine Impurity 103 (CAS CATO-C4X-1467103)
- Phenylephrine Impurity 43 (CAS 2300752-10-5)
- Phenylephrine Impurity 8 (CAS CATO-C4X-14678)
- Phenylephrine Impurity 90 (CAS CATO-C4X-146790)
- Phenylephrine Impurity 10 (CAS 1391194-63-0)
- Phenylephrine Impurity 11 (CAS 1391194-51-6)
- Phenylephrine Impurity 52 (CAS 1785420-81-6)
- Phenylephrine Impurity 9 (CAS 1391194-66-3)
Recommended Standards
- N-(5-Bromo-2-formylphenyl)acetamide (CAS 2137779-54-3)
- Carteolol Impurity 20 (CAS CATO-C4X-228720)
- Methyl 3-bromo-5-ethenylpyridine-4-carboxylate (CAS 2055840-93-0)
- [3-(2-phenylethoxy)phenyl]boranediol (CAS 1029439-94-8)
- Vericiguat Impurity 94 (CAS CATO-C4X-289694)
- Tolvaptan Impurity 29 (CAS 331947-69-4)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- (2S,3S,4S,5R)-2-(ethylthio)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 80763-61-7)
- 2,5-Dichloro-4-methylmandelic acid (CAS 1806347-56-7)
- Benzyl 2-cyclopropylacetate (CAS 59698-18-9)
- 2-(1-Methylazepan-4-yl)acetic acid (CAS 760907-25-3)
- 2’-Methyl-5’-nitroacetophenone (CAS 58966-27-1)
- 2-Chloro-5-(4-methoxycarbonylphenyl)benzoic acid (CAS 1261903-35-8)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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