Phenylephrine Impurity 52 CAS 1785420-81-6
| CAS No. | 1785420-81-6 |
| Molecular Formula | C9H12BrNO2 |
| Molecular Weight | 246.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Phenylephrine Impurity 52 (CAS 1785420-81-6, C9H12BrNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H12BrNO2, Phenylephrine Impurity 52 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 246.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Phenylephrine Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12BrNO2 |
| Molecular Weight | 246.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Phenylephrine Standards
- Phenylephrine Impurity 10 (CAS 1391194-63-0)
- Phenylephrine Impurity 11 (CAS 1391194-51-6)
- Phenylephrine Impurity 9 (CAS 1391194-66-3)
- Phenylephrine-3-O-Sulfate (CAS 1242184-39-9)
- Phenylephrine Impurity 8 (CAS CATO-C4X-14678)
- Phenylephrine Impurity 90 (CAS CATO-C4X-146790)
- Phenylephrine Impurity 103 (CAS CATO-C4X-1467103)
- Phenylephrine impurity 94 (CAS 83070-12-6)
Recommended Standards
- Pinaverium impurity 25 (CAS 89525-51-9)
- WDG35UDX67 5332-26-3 N-(Bromomethyl)phthalimide 1H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)- AI3-28934 EINECS 226-239-2 NSC 3997 Phthalimide, N-(bromomethyl)- Phthalimidomethyl bromide UNII-WDG35UDX67 (CAS 5332-26-3)
- Moxonidine EP Impurity A (CAS 352457-35-3)
- Ethyl 4-Bromo-3,5-dimethyl-1H-pyrrole-2-carboxylate (CAS 5408-07-1)
- Ixazomib Impurity 70 (CAS 1173167-12-8)
- Niraparib Impurity 29 (CAS 2308483-85-2)
- Thioctic Acid Impurity 12 (CAS 916746-61-7)
- 7-Bromo-2,3-dihydrobenzofuran-3-ol (CAS 1404230-46-1)
- Methyl 2-chloro-4-(2,4-difluorophenyl)benzoate (CAS 1820705-05-2)
- 1-Methyl-3-(5-nitrofuran-2-yl)-1h-pyrazol-5-amine (CAS 1152708-32-1)
- Levofloxacin impurity 90 (CAS CATO-C4X-137190)
- N-(4-aminophenyl)ethane-1-sulfonamide (CAS 337912-53-5)
- 3-Bromoquinoline-8-carbaldehyde (CAS 1556231-57-2)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
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