4-Chloro-1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine CAS 832714-08-6
| CAS No. | 832714-08-6 |
| Molecular Formula | C12H9ClN4O2S |
| Molecular Weight | 308.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine.
4-Chloro-1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 832714-08-6), molecular formula C12H9ClN4O2S and molecular weight 308.74 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine (C12H9ClN4O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN4O2S |
| Molecular Weight | 308.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-6-(4-fluorophenyl)-4-phenylnicotinonitrile (CAS 1205028-27-8)
- 1-(3-Chloro-4-methoxyphenyl)-6-mercapto-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 1416344-94-9)
- 2-(3-Chloro-4-hydroxyphenyl)-2-[(3-fluoro-5-methylphenyl)amino]acetamide (CAS 1423358-13-7)
- 3-((5-Chloro-2-hydroxyphenyl)amino)benzo[d]isothiazole 1,1-dioxide (CAS 1432436-96-8)
- 149281-95-8 N-[(2-Chloro-6-fluorophenyl)methyl]-N-methoxy-N'-phenylurea DTXSID40375709 (CAS 149281-95-8)
- ethyl 1-(5-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate (CAS 1909309-82-5)
- ethyl 1-(4-chloro-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate (CAS 1909317-05-0)
- (3-(2-Chloro-6-fluorophenyl)-5-methylisoxazol-4-yl)(pyrrolidin-1-yl)methanone (CAS 288317-52-2)
Recommended Standards
- 4-[(4-Chlorophenyl)sulfanyl]-3-nitrobenzenecarbaldehyde oxime (CAS 477851-86-8)
- 4-chloro-N-(2-methoxy-1-methylethyl)-3-nitrobenzenesulfonamide (CAS 747412-35-7)
- 3-[(1Z)-{[(5-chloro-1,2,3-thiadiazol-4-yl)methoxy]imino}methyl]-2,3-dihydro-1H-indol-2-one (CAS 344277-69-6)
- Methyl 2-(2-(chlorosulfonyl)-4,5-dimethoxyphenyl)acetate (CAS 62208-38-2)
- Ethyl 1-(2-bromoacetyl)-4-piperidinecarboxylate (CAS 102302-12-5)
- 3-(4,5-Dihydro-1H-pyrrol-2-yl)pyridine (CAS 1125-96-8)
- 4-Methoxybenzyl (S)-(1-cyano-2-(4-((((4-methoxybenzyl)oxy)carbonyl)oxy)phenyl)ethyl)carbamate (CAS 73148-72-8)
- N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)-4-nitrobenzamide (CAS 90335-45-8)
- 5α-Pregnan-3β,20α-diol 3-sulfate-D4 (as potassium salt) (CAS CATO-C4X-24432)
- 3-[(1E)-(Dimethylamino)methylidene]-1-(4-fluorophenyl)thiourea (CAS 1661847-01-3)
- 2-(Bicyclo[1.1.1]pentan-1-yl)ethan-1-amine (CAS 2168002-11-5)
- Ethyl 2-(3,4-difluorophenyl)acetate (CAS 129409-55-8)
- 2-Chloro-7-Methylimidazo[1,2-a]pyridine (CAS 189115-88-6)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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