Metoprolol Impurity 32 HCl CAS 83281-59-8
| CAS No. | 83281-59-8 |
| Molecular Formula | C15H23NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Metoprolol Impurity 32 HCl (CAS 83281-59-8), a pharmacopoeial impurity reference standard (molecular formula C15H23NO4HCl, MW 317.81 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Metoprolol Impurity 32 HCl (C15H23NO4HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Metoprolol Impurity 32 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H23NO4 HCl |
| Molecular Weight | 317.81 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoprolol Standards
- Metoprolol EP Impurity A (CAS 109632-08-8)
- Metoprolol Impurity 23 (CAS 109632-11-3)
- Metoprolol Impurity 9 (CAS 1155083-53-6)
- Metoprolol Acid-d5 Ethyl Ester (CAS 1189704-28-6)
- Metoprolol Fumarate (CAS 119637-66-0)
- Metoprolol Acid-d5 (CAS 1215404-47-9)
- Metoprolol-D7 Hydrochloride (CAS 1219798-61-4)
- Metoprolol Impurity 22 (CAS 123195-72-2)
Recommended Standards
- Etrasimod impurity 17 (CAS CATO-C4X-321417)
- Tibolone EP Impurity A (CAS CATO-C4X-240312)
- Lifitegrast Impurity 126 (CAS CATO-C4X-2409126)
- ethyl (2R,4R,5R)-5-hydroxy-2-methyl-piperidine-4-carboxylate (CAS 2816820-69-4)
- 2-(Styrylthio)acetic Acid (CAS 13435-97-7)
- Estriol Impurity 26 (CAS CATO-C4X-163726)
- 2-(4-Imidazolyl)acetonitrile (CAS 18502-05-1)
- 3425-46-5 Potassium selenocyanate Selenocyanic acid, potassium salt Selenocyanic acid, potassium salt (1:1) CCRIS 7063 EINECS 222-320-1 Potassium selenoisocyanate (CAS 3425-46-5)
- 1,2,4-Trimethyl-2,5-diazabicyclo[2.2.2]octane-3,6-dione (CAS 817575-51-2)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com