Metoprolol Impurity 9 CAS 1155083-53-6
| CAS No. | 1155083-53-6 |
| Molecular Formula | C12H16O3 |
| Molecular Weight | 208.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Metoprolol Impurity 9.
As a process- or degradation-related impurity, Metoprolol Impurity 9 (CAS 1155083-53-6, C12H16O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Metoprolol Impurity 9 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16O3 |
| Molecular Weight | 208.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
Related Metoprolol Standards
- Metoprolol Impurity 18 (CAS 56718-70-8)
- Metoprolol Impurity 29 (CAS 89507-60-8)
- Metoprolol Impurity 21 (CAS 84697-14-3)
- Metoprolol EP Impurity F (CAS 7695-63-8)
- Metoprolol Impurity 22 (CAS 123195-72-2)
- Metoprolol Impurity 17 (CAS 158553-31-2)
- Metoprolol Impurity 27 (CAS 40167-10-0)
- Metoprolol EP Impurity D (CAS 62572-90-1)
Recommended Standards
- 4,5-Diethoxy-2-methylbenzaldehyde (CAS 1151530-42-5)
- (R)-Methyl 3-(benzyloxy)butanoate (CAS 116761-24-1)
- 1-(4-Hydroxy-3-methoxyphenyl)pentan-1-one (CAS 114515-51-4)
- tert-Butyl 2-hydroxy-2-phenylacetate (CAS 117356-18-0)
- Clotrimazole EP Impurity A (CAS 66774-02-5)
- Rosuvastatin Impurity 43 (CAS 1378943-63-5)
- Roxatidine Impurity 14 (CAS CATO-C4X-121314)
- 3-((2,3-Dichlorophenoxy)methyl)-4-methoxybenzohydrazide (CAS 438218-58-7)
- 2-Methoxy-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine (CAS 947305-13-7)
- (1R,2R)-3,3-Dimethylcyclopropane-1,2-dicarboxylic acid (CAS 1701-82-2)
- 1-(4-Hydroxycinnolin-3-yl)ethanone (CAS 136920-49-5)
- 2-(3-Butoxyphenyl)-6,8-dimethylquinoline-4-carboxylic acid (CAS 932841-33-3)
- Fluralaner Impurity 18 (CAS CATO-C4X-218018)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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